Urological Science

EDITORIAL COMMENT
Year
: 2020  |  Volume : 31  |  Issue : 3  |  Page : 114-

Editorial comment: The impact of pseudoephedrine and antihistamine on lower urinary tract symptoms in male patients with rhinitis: A prospective randomized study


Chung-Cheng Wang 
 Department of Urology, En Chu Kong Hospital, Sanxia District, New Taipei City, Taiwan

Correspondence Address:
Chung-Cheng Wang
Department of Urology, En Chu Kong Hospital, Sanxia District, New Taipei City
Taiwan




How to cite this article:
Wang CC. Editorial comment: The impact of pseudoephedrine and antihistamine on lower urinary tract symptoms in male patients with rhinitis: A prospective randomized study.Urol Sci 2020;31:114-114


How to cite this URL:
Wang CC. Editorial comment: The impact of pseudoephedrine and antihistamine on lower urinary tract symptoms in male patients with rhinitis: A prospective randomized study. Urol Sci [serial online] 2020 [cited 2023 Feb 5 ];31:114-114
Available from: https://www.e-urol-sci.com/text.asp?2020/31/3/114/287978


Full Text



Acute urinary retention has association with the use of drugs with anticholinergic activity (e.g., antihistamine, alpha-adrenoceptor agonists, antipsychotic drugs, antidepressant agents, opioids and anesthetics, benzodiazepines, and calcium-channel antagonists). Elderly patients are at higher risk of drug-induced urinary retention happening because of existing comorbidities such as benign prostatic hyperplasia, diabetes mellitus, neurological diseases, and the use of other concomitant medications that could reinforce the impairing effect on micturition. We congratulated Lee CC et al. conducted the prospective randomized study to investigate the impact of pseudoephedrine and antihistamine on lower urinary tract symptoms (LUTSs) in “asymptomatic” male patients with rhinitis. The main conclusion was that although the effect of both medications on LUTS was limited, pseudoephedrine worsened International Prostate Symptom Score – Total (IPSST) in elderly men, whereas antihistamines worsened IPSS-V in younger men. In self-unaware voiding dysfunction males with IPSS-T>7, pseudoephedrine may cause more Post-voiding residual urine volume (PVR).

These findings were intriguing. However, in clinical practice, otolaryngologist usually prescribes both medications for patients with rhinitis. The synergic effects on LUTS should be investigated. In addition, the pathophysiology of lower urinary tract dysfunction was multifactorial and complex. We encouraged the authors to collect more clinical data (e.g., prostate size, uroflowmetry, aged people, both genders, comorbidities, other medications, the severity, and disease duration of rhinitis) to construct a LUTS model for patients with rhinitis.