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REVIEW ARTICLE
Year : 2022  |  Volume : 33  |  Issue : 4  |  Page : 161-169

The cancer behavior and current treatment strategy for upper urinary tract cancer


1 Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
2 Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University; Department of Urology, Kaohsiung Medical University Hospital; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University; Department of Urology, Kaohsiung Municipal Ta-Tung Hospital; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University; Center for Stem Cell Research, Kaohsiung Medical University; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung, Taiwan

Correspondence Address:
Wen-Jeng Wu
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung; Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung; Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung; Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/UROS.UROS_58_22

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Upper urinary tract urothelial carcinomas (UTUCs) are rare diseases, accounting for only 5%–10% of all urothelial cancers. Radical nephroureterectomy (RNU) with bladder cuff excision remains the standard care modality of UTUCs. However, the prognosis is poor and the recurrence is high in patients with advanced UTUC treated with RNU currently. Therefore, identifying cancer behavior for UTUC is an important guide for clinical practice. Herein, we provide an overview of cancer behavior of UTUCs, including prognostic factors and clinical cancer courses. We also discuss the appropriate management of patients with UTUC, such as diagnosis, surgical management, and systemic therapies. Due to the rarity of UTUC, strong evidence of management is often lacking. Therefore, further prospective trials are needed, and regular follow-up after interventions is mandatory.


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