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The risk of subsequent malignancies in patients with renal cell carcinoma: A nationwide, population-based study
Yu-Cheng Lu1, Yu-Chieh Tsai2, Po-Ming Chow1, Wen-Ching Weng3, Wei-Yi Huang4, Shih-Chieh Jeff Chueh1, Kao-Lang Liu5, Kuo-How Huang1
1 Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
2 Department of Oncology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
3 Department of Surgery, Kinmen Hospital; Department of Health, Executive Yuan; Institute of Health and Welfare Policy, National Yang-Ming University, Taipei, Taiwan
4 Institute of Health and Welfare Policy, National Yang-Ming University; Department of Health, NHI Medical Expenditure Negotiation Committee, Executive Yuan, Taipei, Taiwan
5 Department of Medical Imagine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
Correspondence Address:
Kao-Lang Liu
Medical Imagine, National Taiwan University Hospital, 7 Chung-Shan South Road, Zhongzheng District, Taipei 100
Taiwan
Kuo-How Huang
Department of Urology, National Taiwan University Hospital, 7 Chung-Shan South Road, Zhongzheng District, Taipei 100
Taiwan
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/UROS.UROS_135_21
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Purpose: The purpose was to investigate the risk of subsequent malignancies in patients with renal cell carcinoma (RCC) using hospital-based cancer registry database and a nationwide health insurance database. Materials and Methods: We used the following three databases: Cancer Registry Database of National Taiwan University Hospital (NTUH), National Health Insurance Research Database (NHIRD), and registry for catastrophic illness patients, a subset from NHIRD. We identified patients with RCC and analyzed the risk of subsequent malignancies in these patients. Results: Of the 1188 patients with RCC treated at NTUH, 141 (11.9%) had subsequent malignancies. Cancers in the colon, liver, prostate, lung and stomach were the five most common other primary malignancies. The nationwide analysis showed that 4.68% of the RCC patients had subsequent malignancies. The percentage was significantly higher than that in the general population in Taiwan. The five most common subsequent malignancies in patients with RCC were bladder, liver, colon, lung, and prostate cancer. The risk of developing these subsequent cancers in RCC patients was also significantly higher than that in the general population. Conclusion: Subsequent malignancies were noted in a high proportion of patients with RCC in Taiwan. It is a multifactorial process and the mechanism is still uncertain. This important issue warrants further studies to elucidate the mechanism.
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