A short term follow up for intracavernosal injection of platelet rich plasma for the treatment of erectile dysfunction

Shin-Mei Wong; Bing-Juin Chiang; Hui-Chun Chen; Yi-No Wu; Ying-Hung Lin; Chun-Hou Liao

doi:10.4103/UROS.UROS_22_21

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ORIGINAL ARTICLE

Year : 2021 \| Volume : 32 \| Issue : 4 \| Page : 171-176

A short term follow up for intracavernosal injection of platelet rich plasma for the treatment of erectile dysfunction Shin-Mei Wong¹, Bing-Juin Chiang², Hui-Chun Chen³, Yi-No Wu⁴, Ying-Hung Lin⁵, Chun-Hou Liao⁶ ¹ Division of Urology, Department of Surgery, Cardinal Tien Hospital, New Taipei City, Taiwan ² Division of Urology, Department of Surgery, Cardinal Tien Hospital, New Taipei City; Department of Life Science, College of Science, National Taiwan Normal University, Taipei; School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan ³ Department of Nursing, Chang Gung University of Science and Technology, New Taipei City, Taiwan ⁴ School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan ⁵ Graduate Institute of Biomedical and Pharmaceutical Science, Fu-Jen Catholic University, New Taipei City, Taiwan ⁶ Division of Urology, Department of Surgery, Cardinal Tien Hospital; School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan Correspondence Address: Prof. Chun-Hou Liao Divisions of Urology, Department of Surgery, Cardinal Tien Hospital, No. 362, Zhong-Zheng Road, XinDian District, New Taipei City 23148 Taiwan Assoc. Prof. Ying-Hung Lin Graduate Institute of Biomedical and Pharmaceutical Science, Fu-Jen Catholic University, No. 510 Zhongzheng Road, Xinzhuang District, New Taipei City 242 Taiwan Source of Support: None, Conflict of Interest: None DOI: 10.4103/UROS.UROS_22_21

Purpose: The objective of this study was to investigate the safety and efficacy of intracavernosal platelet-rich plasma (PRP) injection in patients with erectile dysfunction (ED). Materials and Methods: Between September 2018 and September 2020, thirty participants with ED were enrolled in this prospective single-arm study. All participants received three sessions of intracavernosal PRP injection. Oral phosphodiesterase type 5 (PDE5) inhibitors or testosterone replacement therapy (TRT) without a change in dosing was permitted during the treatment period. Efficacy was assessed using the International Index of Erectile Function-5 (IIEF-5), Erectile Hardness Score (EHS), Sexual Encounter Profile (SEP) 2 and 3, and Global Assessment Question, every 2 weeks after each treatment session. Any adverse events were recorded. Results: The mean age of participants was 54.93 years. Oral PDE5 inhibitors were prescribed to 76.7% of participants (n = 23), and 50% of participants (n = 15) received concurrent TRT. A significant improvement in erectile function was measured by an average of 4.556 points in IIEF-5 (P < 0.001) and 0.72 points in EHS (P < 0.001). In total, 4 (13.3%) and 15 (50%) participants reported “no” to “yes” in SEP2 and SEP3 questions after therapy, respectively. Overall, 82.8% of participants agreed that the study therapy improved erectile function. No significant adverse events were reported. Conclusion: This single-arm prospective study revealed that preliminary experience with penile PRP significantly improves erectile function without obvious adverse events.



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