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REVIEW ARTICLE
Year : 2021  |  Volume : 32  |  Issue : 4  |  Page : 143-150

Mitochondrial dysfunction in patients with urogenital disease


1 Division of Urology, Taipei City Hospital Zhongxiao Branch, Taipei, Taiwan
2 Division of Urology, Taipei City Hospital Zhongxiao Branch; Department of Urology, School of Medicine, National Yang-Ming Chiao Tung University; Commission for General Education, National Taiwan University of Science and Technology; General Education Center, University of Taipei, Taipei, Taiwan
3 Division of Urology, Taipei City Hospital Zhongxiao Branch; Department of Urology, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
4 Center for Mitochondrial Medicine and Free Radical Research, Changhua Christian Hospital, Changhua City, Taiwan

Correspondence Address:
Dr. Yau-Huei Wei
Center for Mitochondrial Medicine and Free Radical Research, Changhua Christian Hospital, No. 176, 6th Floor, Zhonghua Road, Changhua 50046
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/UROS.UROS_47_21

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Mitochondria are intracellular organelles responsible for the production of the majority of adenosine triphosphate (ATP). In addition to energy production, mitochondria also contribute to cellular apoptosis, the regulation of intracellular Ca2+ homeostasis, signaling through reactive oxygen species (ROS), and the coordination of the cell cycle. The prevalence rate of primary mitochondrial disease was estimated at nearly 1:5000. In this review, we have integrated recent evidence to discuss new insights into how mitochondrial dysregulation plays a role in bladder dysfunction, reproductive disorder and the correlation between mtDNA mutation and bladder cancer.


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