|Year : 2021 | Volume
| Issue : 4 | Page : 141-142
Department of Urology, The Center of Excellence in Shockwave Medicine and Tissue Regeneration, Kaohsiung Chang Gung Memorial Hospital; College of Medicine, Chang Gung University, Kaohsiung, Taiwan
|Date of Submission||18-Nov-2021|
|Date of Acceptance||18-Nov-2021|
|Date of Web Publication||14-Dec-2021|
Prof. Yao-Chi Chuang
Department of Urology, The Center of Excellence in Shockwave Medicine and Tissue Regeneration, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Chuang YC. Editorial. Urol Sci 2021;32:141-2
This issue includes a review article on mitochondrial dysfunction in some urological diseases, in uro-oncology, endourology, and andrology for male infertility and erectile dysfunction, and surgical techniques to refine our knowledge and practice in urology.
Mitochondria are intracellular organelles that produce most of the adenosine triphosphate. Mitochondrial dysfunction strongly impacts some urological diseases. Chang and Wei et al. have recently shown evidence to discuss new insights into how mitochondrial dysregulation contributes to bladder dysfunction and reproductive disorder and the correlation between mitochondrial DNA (mtDNA) and bladder cancer.
Tseng et al. compared the differences in long-term oncological outcomes between patients who underwent radical cystectomy (RC) or bladder-sparing trimodal therapy (TMT) using maximal transurethral resection of bladder tumor, followed by radiation therapy with concomitant radiosensitizing chemotherapy for muscle-invasive bladder cancer (MIBC).
They found no significant survival benefit for MIBC with either RC or TMT. However, RC is associated with better outcomes of disease-free survival rate, especially in patients with early stages of MIBC stages T2 and N0.
Lu et al. evaluated the incidence and clinical features of 23 patients who had undergone nephroureterectomy with nonmalignant upper tract lesions presumed to be urothelial carcinoma from images in Taiwan. They found that self-voided urine cytology provided limited diagnostic information in this group, and in 75% of patients with nonfunctional kidney, nephroureterectomy may be a feasible diagnostic and therapeutic method.
Lai et al. sought to improve the methods for tissue collection by avoiding considerable loss in the viability of cells for further analyses caused by increased quantities of degraded proteins and RNA. They concluded that once removed from the human body, tumor samples should be processed or frozen freshly within 30 min. Furthermore, transurethral biopsy of the bladder tumor is considered a better method to collect samples for further molecular oncology studies.
Wong et al. investigated the safety and efficacy of intracavernosal platelet-rich plasma injection in 23 patients with erectile dysfunction from a single-arm study. Interestingly, 82.8% of participants agreed that the study therapy improved erectile function. No significant adverse events were reported.
Tsai et al. described and validated a method used to calculate the ureteral length using computed tomography (CT) images acquired before ureteral stent placement and to evaluate the appropriateness.
They found that the patient's height correlated significantly with CT-derived measurements of ureteral length. Comparing the proposed and actual stent sizes in the 13 patients showed the percentage of size appropriateness (as defined by concordance between proposed and actual stent lengths) to be 76.9% (10/13).
Atac et al. aimed to investigate the effect of varicocelectomy on sleep quality and testosterone levels in 39 patients with painful left grade 3 varicocele. They found that after varicocelectomy, sleep quality remarkably improved in addition to pain relief (92.3% of patients) and increase of testosterone level (82.0% of patients).
Huang et al. evaluated the correlation between different semen parameters and sperm DNA fragmentation (SDF) to identify the most suitable predictor of abnormal SDF. They suggested that sperm motility is the most predictive and relevant parameter to predict the abnormal SDF. Suboptimal sperm motility should be considered an indication for SDF testing.
We hope that you find these articles relevant to your knowledge of urology.
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