| ORIGINAL ARTICLE |
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| Year : 2018 | Volume
: 29
| Issue : 4 | Page : 180-185 |
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Antilithiatic and hepatoprotective effects of Ferula assa-foetida oleo-gum-resin on ethylene glycol-induced lithiasis in rats
Seyyed Majid Bagheri1, Maryam Yadegari2, Maliheh Behpur1, Davood Javidmehr3
1 Department of Physiology, Shahid Sadoughi University of Medical Sciences, Yard, Iran
2 Department of Anatomy, Shahid Sadoughi University of Medical Sciences, Yard, Iran
3 Department of Pathology, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yard, Iran
Correspondence Address:
Seyyed Majid Bagheri
Department of Physiology, Shahid Sadoughi University of Medical Sciences, Prof. Hesabi Bulvd, Shohadaye Gomnam Bulvd, Yard
Iran
 Source of Support: None, Conflict of Interest: None  | 3 |
DOI: 10.4103/UROS.UROS_10_18
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Objective: In this study, antiurolithiasic and hepatoprotective effects of Ferula assa-foetida oleo-gum-resin (asafoetida) were evaluated in Wistar rats. Methods: Negative control rats were provided with ethylene glycol (EG, 1%) in drinking water for 28 days. In treatment group, asafoetida was used simultaneously once daily for 28 days at the dose of 25 mg/kg. 8-h urine was collected from experimental animals at the end of the experiment. Urine level of creatinine, uric acid, urea, K+, Ca2+, Mg2+, Na+, phosphorus, and serum level of transaminase (alanine aminotransferase (ALT) and aspartate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were evaluated. In addition, histopathological changes in kidney and liver were stained in hematoxylin and eosin. Results: Asafoetida showed a significant effect on urine volume; water intake and urinary ionic parameters were altered by EG, which elevated the calcium and inorganic phosphate; and asafoetida significantly reduced the elevated levels of these ions. In addition, asafoetida significantly elevated the urinary concentration of magnesium. ALT, AST, LDH, and ALP were elevated by EG and asafoetida significantly reduced the elevated levels of these parameters. The histological findings also showed improvement after treatment with the asafoetida. Conclusion: The presented data indicate that administration of asafoetida prevented the growth of urinary stones and also have hepatoprotective effect in experimental EG nephrolithiasis in Wistar rats.
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